Effect of melatonin on insomnia and daytime sleepiness, in patients with obstructive sleep apnea and insomnia (COMISA): A randomized double-blinded placebo-controlled trial.
We investigated how melatonin affects patients with obstructive sleep apnea and insomnia. In a double-blind trial, thirty patients received either 10 mg of melatonin or a placebo for a month.
The results were striking; those taking melatonin reported better sleep quality, less daytime sleepiness, and greater adherence to their PAP devices. Improvements were noted across several assessments: the Pittsburgh Sleep Quality Index, Insomnia Severity Index, Epworth Sleepiness Scale, and Functional Outcomes of Sleep Questionnaire showed significant gains for the melatonin group.
Thus, melatonin appears to be a promising option to enhance sleep quality and treatment compliance in this challenging patient group.
Read More
7
Agomelatine shows promise for OSA
Evaluating the Effects of Agomelatine on Polysomnography Parameters in Patients with Obstructive Sleep Apnea.
We conducted a study to see if agomelatine, a melatonin-based drug, could help patients with obstructive sleep apnea (OSA). In this randomized and single-blind trial, seventy adults took either agomelatine or a placebo for three nights before sleep testing.
The results showed that agomelatine improved total sleep time, sleep efficiency, and reduced waking percentage compared to the control group. However, other sleep parameters did not show significant changes. Overall, agomelatine may be beneficial for those struggling with OSA.
Read More
7
Melatonin's role in sleep apnea
Melatonin mediates intestinal barrier dysfunction and systemic inflammation in moderate-severe OSA patients.
We explored how melatonin, known for its anti-inflammatory properties, interacts with obstructive sleep apnea (OSA) and related health issues.
In a study of 235 men experiencing sleep problems, we found that higher OSA severity correlated with lower melatonin levels and increased markers of intestinal barrier dysfunction and inflammation.
Melatonin appeared to mediate these relationships, explaining a significant portion of the connection between apnea severity and these harmful conditions. However, the overall results suggest that while melatonin is connected to inflammation and intestinal issues in OSA, it does not appear to solve these complications.
Read More
Most Useful Reviews
10
Improved sleep quality
134 people found this helpful
These Melatonin gummies have truly transformed my life! My son, who previously refused to sleep until late and woke up at 3 or 4 am, is now going to bed at 8 o'clock and waking up at 6. I initially started with one gummy, but found that two work better for him. Every child is different, of course!
Read More
9
Supports hyperactive children
50 people found this helpful
For children with hyperactivity that makes sleep difficult, I strongly recommend this product. Giving them half a gummy about twenty minutes before bed works wonders—they finally get the sleep they need.
Read More
9
Child sleeps well
43 people found this helpful
These gummies are fantastic; my child sleeps soundly after taking them. They are delicious and encourage restful sleep, which is what we desperately needed.
Effect of melatonin on insomnia and daytime sleepiness, in patients with obstructive sleep apnea and insomnia (COMISA): A randomized double-blinded placebo-controlled trial.
We investigated how melatonin affects patients with obstructive sleep apnea and insomnia. In a double-blind trial, thirty patients received either 10 mg of melatonin or a placebo for a month.
The results were striking; those taking melatonin reported better sleep quality, less daytime sleepiness, and greater adherence to their PAP devices. Improvements were noted across several assessments: the Pittsburgh Sleep Quality Index, Insomnia Severity Index, Epworth Sleepiness Scale, and Functional Outcomes of Sleep Questionnaire showed significant gains for the melatonin group.
Thus, melatonin appears to be a promising option to enhance sleep quality and treatment compliance in this challenging patient group.
Read More
7
Melatonin's role in sleep apnea
Melatonin mediates intestinal barrier dysfunction and systemic inflammation in moderate-severe OSA patients.
We explored how melatonin, known for its anti-inflammatory properties, interacts with obstructive sleep apnea (OSA) and related health issues.
In a study of 235 men experiencing sleep problems, we found that higher OSA severity correlated with lower melatonin levels and increased markers of intestinal barrier dysfunction and inflammation.
Melatonin appeared to mediate these relationships, explaining a significant portion of the connection between apnea severity and these harmful conditions. However, the overall results suggest that while melatonin is connected to inflammation and intestinal issues in OSA, it does not appear to solve these complications.
Read More
7
Agomelatine shows promise for OSA
Evaluating the Effects of Agomelatine on Polysomnography Parameters in Patients with Obstructive Sleep Apnea.
We conducted a study to see if agomelatine, a melatonin-based drug, could help patients with obstructive sleep apnea (OSA). In this randomized and single-blind trial, seventy adults took either agomelatine or a placebo for three nights before sleep testing.
The results showed that agomelatine improved total sleep time, sleep efficiency, and reduced waking percentage compared to the control group. However, other sleep parameters did not show significant changes. Overall, agomelatine may be beneficial for those struggling with OSA.
Read More
7
REM Sleep Behavior Disorder Overview
REM sleep behavior disorder as a complex condition with heterogeneous underlying disorders: clinical management and prognostic implications [Commentary].
We explored REM sleep behavior disorder (RBD) as a complex condition that can be linked to a variety of underlying disorders. Through a literature review and insights from foundational texts, we recognized that RBD may emerge at any age and can initially appear as an isolated issue or be associated with other significant conditions like Parkinson’s and narcolepsy.
Our findings highlighted that effective management often includes melatonin or clonazepam as treatment options. Furthermore, ongoing research into the connections between RBD and other sleep disorders, such as obstructive sleep apnea, remains vital for enhancing diagnostics and treatment strategies.
Read More
User Reviews
USERS' SCORE
Good
Based on 135 Reviews
8.4
All Reviews
Positive Reviews
Negative Reviews
10
Improved sleep quality
134 people found this helpful
These Melatonin gummies have truly transformed my life! My son, who previously refused to sleep until late and woke up at 3 or 4 am, is now going to bed at 8 o'clock and waking up at 6. I initially started with one gummy, but found that two work better for him. Every child is different, of course!
Read More
9
Supports hyperactive children
50 people found this helpful
For children with hyperactivity that makes sleep difficult, I strongly recommend this product. Giving them half a gummy about twenty minutes before bed works wonders—they finally get the sleep they need.
Read More
9
Child sleeps well
43 people found this helpful
These gummies are fantastic; my child sleeps soundly after taking them. They are delicious and encourage restful sleep, which is what we desperately needed.
Read More
9
Good for tired children
42 people found this helpful
I’ve had excellent experiences with this product. It makes my child sleepy after just half an hour, which is a relief! The taste is nice too, and it's good to know children can’t open the package themselves. I highly recommend it as a safe option.
Read More
10
Quick sleep onset
24 people found this helpful
This product came as a delightful surprise. My son has been very active and had trouble sleeping. After taking just half an hour post-ingestion, he fell into a deep sleep, proving highly effective. I rate this product exceptionally highly!
Sleep apnea is a common and potentially serious sleep disorder characterized by irregular breathing patterns during sleep. Individuals with sleep apnea experience episodes of disrupted or paused breathing, which can occur multiple times throughout the night. These interruptions can last a few seconds to several minutes and often lead to fragmented sleep, which may result in excessive daytime sleepiness, irritability, and difficulty concentrating. The condition can be broadly classified into two main types: obstructive sleep apnea (OSA), caused by a blockage of the upper airway, and central sleep apnea (CSA), which occurs when the brain fails to send the proper signals to the muscles that control breathing.
The diagnosis of sleep apnea typically involves a sleep study, either conducted in a sleep clinic or at home using portable monitoring devices. Treatment options vary depending on the severity of the condition but may include lifestyle changes, the use of continuous positive airway pressure (CPAP) machines, oral appliances, or even surgery in some cases. If left untreated, sleep apnea can lead to various health complications, including cardiovascular issues, metabolic disorders, and impaired cognitive function, making it essential to consult a healthcare professional if you suspect you or someone you know may be affected by this disorder.
Children's sleep aids are products designed to help improve sleep quality and ease the process of falling asleep for kids. These aids can include various forms such as melatonin supplements, bedtime routines, calming teas, and even sleep-inducing sound machines or night lights. Melatonin, a hormone that regulates sleep-wake cycles, is commonly used in supplement form, but it’s essential to consult with a pediatrician before introducing any sleep aid to ensure it's appropriate for your child’s age and health.
In addition to supplements, creating a conducive sleep environment is crucial. This includes establishing a consistent bedtime routine, limiting screen time before bed, and ensuring the bedroom is dark, quiet, and cool. Utilizing tools like weighted blankets or soothing sounds can also promote a peaceful sleep setting. Always prioritize healthy sleep habits and discuss persistent sleep issues with a healthcare professional to find the most suitable solutions for your child's sleep challenges.
Based on user reviews, many individuals report seeing results from this melatonin supplement within approximately 30 minutes after ingestion. For instance, one user noted that their child was able to fall asleep deeply within half an hour after taking a gummy Read Review. Another parent mentioned that their children began sleeping faster and more soundly, indicating noticeable improvement after just a few doses Read Review.
While many users experienced positive changes in their children's sleep patterns relatively quickly, some reviews indicate that consistent use over a few nights may further enhance the effectiveness of the supplement. One parent shared that after three nights of use, their children started to sleep better and woke up feeling refreshed Read Review. Overall, while results can vary depending on the individual, many families have successfully found relief for sleep issues within a short time frame.
Melatonin has shown promise in the realm of sleep apnea, particularly in obstructive sleep apnea (OSA) and insomnia. A double-blind study involving thirty patients indicated that those who took melatonin experienced notable improvements in sleep quality, reduced daytime sleepiness, and higher adherence to their Positive Airway Pressure (PAP) devices. The results, assessed through various sleep quality indices, demonstrated that melatonin could enhance treatment compliance in this challenging patient group [2]. However, while there is a correlation between lower melatonin levels and increased severity of OSA, it does not conclusively address the complexities associated with this sleep disorder [1].
Moreover, agomelatine, a melatonin-based medication, yielded positive results in a study focused on its effects on OSA patients, highlighting improvements in total sleep time and sleep efficiency [3]. Although melatonin may not be a standalone solution, it appears to be a beneficial adjunctive option for managing OSA symptoms, particularly in enhancing sleep quality and adherence to treatments. Researchers suggest that ongoing studies concerning melatonin’s role in sleep apnea can provide deeper insights into its efficacy and complementary use with existing therapies [4].
Many users have reported significant improvements in their children's sleep patterns after using melatonin gummies. For instance, one parent shared that their son, who previously struggled to fall asleep until very late, now goes to bed at a reasonable hour and wakes up early, a drastic change from his former routine Read Review. Another user observed that their child with hyperactivity began sleeping better consistently after just a half of a gummy taken before bedtime Read Review.
Numerous endorsements also highlight the quick onset of sleep, with some children falling asleep within 15 to 30 minutes of taking the gummies Read Review. Reviewers mentioned reduced nighttime awakenings, improved mood, and more peaceful evenings Read Review. Families have found that these gummies not only promote better sleep but also help alleviate the stress associated with bedtime routines Read Review. While individual results may vary, these anecdotal experiences suggest that melatonin gummies can be a valuable tool for parents seeking effective solutions for their children’s sleep challenges.
When considering the optimal dose for children's sleep aids related to treating sleep apnea, research highlights the efficacy of melatonin. Studies suggest a dosage of 10 mg for melatonin can significantly improve sleep quality and reduce daytime sleepiness in patients, including those with obstructive sleep apnea (OSA) and insomnia [2]. This dose has shown positive results in enhancing treatment adherence and overall sleep quality as assessed through multiple sleep quality indices.
Additionally, melatonin's role extends beyond mere sleep enhancement; it also has anti-inflammatory properties that may interact with the complications posed by OSA [1]. Despite the positive findings, it is essential to note that while higher melatonin levels are correlated with better sleep quality, research indicates that melatonin does not necessarily resolve the underlying issues associated with OSA. Therefore, while 10 mg appears to be the optimal dose for improving sleep outcomes, careful consideration should be given to individual needs and professional guidance is recommended for any sleep aids in children.
10
Quick sleep onset
24 people found this helpful
This product came as a delightful surprise. My son has been very active and had trouble sleeping. After taking just half an hour post-ingestion, he fell into a deep sleep, proving highly effective. I rate this product exceptionally highly!
9.5
Improved sleep pattern
9 people found this helpful
After giving my children this product a few times, I noticed they began sleeping faster and more deeply, without interruptions. They now wake up energetic, and the effects last for a month. It takes about half an hour to work, and the large package is very beneficial.
10
Improved sleep quality
134 people found this helpful
These Melatonin gummies have truly transformed my life! My son, who previously refused to sleep until late and woke up at 3 or 4 am, is now going to bed at 8 o'clock and waking up at 6. I initially started with one gummy, but found that two work better for him. Every child is different, of course!
9
Supports hyperactive children
50 people found this helpful
For children with hyperactivity that makes sleep difficult, I strongly recommend this product. Giving them half a gummy about twenty minutes before bed works wonders—they finally get the sleep they need.
9
Assists with sleep
14 people found this helpful
Excellent! This sweet helps regulate my children's sleep when needed. They typically fall asleep within 15 minutes after taking it. I’ve also used it personally and found it beneficial.
9
Deep, restful sleep
9 people found this helpful
This has been a lifesaver for our family! My son struggled to sleep from age four, causing us all stress. Now, I give him a pill at 8pm, and he drifts off an hour later. His sleep is deep and revitalising, and I have noticed no side effects.
9.5
Melatonin improves sleep apnea outcomes
Effect of melatonin on insomnia and daytime sleepiness, in patients with obstructive sleep apnea and insomnia (COMISA): A randomized double-blinded placebo-controlled trial.
We investigated how melatonin affects patients with obstructive sleep apnea and insomnia. In a double-blind trial, thirty patients received either 10 mg of melatonin or a placebo for a month.
The results were striking; those taking melatonin reported better sleep quality, less daytime sleepiness, and greater adherence to their PAP devices. Improvements were noted across several assessments: the Pittsburgh Sleep Quality Index, Insomnia Severity Index, Epworth Sleepiness Scale, and Functional Outcomes of Sleep Questionnaire showed significant gains for the melatonin group.
Thus, melatonin appears to be a promising option to enhance sleep quality and treatment compliance in this challenging patient group.
7
Melatonin's role in sleep apnea
Melatonin mediates intestinal barrier dysfunction and systemic inflammation in moderate-severe OSA patients.
We explored how melatonin, known for its anti-inflammatory properties, interacts with obstructive sleep apnea (OSA) and related health issues.
In a study of 235 men experiencing sleep problems, we found that higher OSA severity correlated with lower melatonin levels and increased markers of intestinal barrier dysfunction and inflammation.
Melatonin appeared to mediate these relationships, explaining a significant portion of the connection between apnea severity and these harmful conditions. However, the overall results suggest that while melatonin is connected to inflammation and intestinal issues in OSA, it does not appear to solve these complications.
7
Agomelatine shows promise for OSA
Evaluating the Effects of Agomelatine on Polysomnography Parameters in Patients with Obstructive Sleep Apnea.
We conducted a study to see if agomelatine, a melatonin-based drug, could help patients with obstructive sleep apnea (OSA). In this randomized and single-blind trial, seventy adults took either agomelatine or a placebo for three nights before sleep testing.
The results showed that agomelatine improved total sleep time, sleep efficiency, and reduced waking percentage compared to the control group. However, other sleep parameters did not show significant changes. Overall, agomelatine may be beneficial for those struggling with OSA.
7
REM Sleep Behavior Disorder Overview
REM sleep behavior disorder as a complex condition with heterogeneous underlying disorders: clinical management and prognostic implications [Commentary].
We explored REM sleep behavior disorder (RBD) as a complex condition that can be linked to a variety of underlying disorders. Through a literature review and insights from foundational texts, we recognized that RBD may emerge at any age and can initially appear as an isolated issue or be associated with other significant conditions like Parkinson’s and narcolepsy.
Our findings highlighted that effective management often includes melatonin or clonazepam as treatment options. Furthermore, ongoing research into the connections between RBD and other sleep disorders, such as obstructive sleep apnea, remains vital for enhancing diagnostics and treatment strategies.
References
Wei Z, Shen H, Wang F, Huang W, Li X, et al. Melatonin mediates intestinal barrier dysfunction and systemic inflammation in moderate-severe OSA patients. Ann Med. 2024;56:2361825. doi:10.1080/07853890.2024.2361825
Motlaq TM, Rahimi B, Amini S. Effect of melatonin on insomnia and daytime sleepiness, in patients with obstructive sleep apnea and insomnia (COMISA): A randomized double-blinded placebo-controlled trial. J Pharm Health Care Sci. 2024;10:25. doi:10.1186/s40780-024-00347-9
Dastan F, Gholizadeh Niari B, Adimi Naghan P, Barati S, Eskandari R. Evaluating the Effects of Agomelatine on Polysomnography Parameters in Patients with Obstructive Sleep Apnea. J Pharm Pharm Sci. 2023;25:418. doi:10.18433/jpps33252
Schenck CH. REM sleep behavior disorder as a complex condition with heterogeneous underlying disorders: clinical management and prognostic implications [Commentary]. Sleep Breath. 2022;26:1289. doi:10.1007/s11325-022-02574-6